Toxic Epidermal Necrolysis details and treatments

Toxic Epidermal Necrolysis details and treatments


 Toxic epidermal necrolysis (TEN) is a rare life-threatening skin disorder characterised by epidermal ulceration and skin tenderness. It is usually triggered by a drug effect.


Special Information:

Symptoms: TEN causes heavy bleeding, rash and diffuse burning sensation. It can affect the nervous system and the intestines.

Causes: The main causes are drug abuse, such as antibiotics, anticonvulsants, and non-steroidal anti-inflammatory drugs (NSA IDs).

treatment:

Supportive care: The cornerstone of treatment is clinical supportive care, usually in an intensive care unit or burn unit. This includes fluid replacement, wound care, and pain management.

Skin Care: Chlorhexidine cream can be used to cleanse the skin and petrolatum white to moisturise the skin. Oral rinses can help deal with gum ulcers.

Airway management: Ensuring that the patient’s airway is clear and secure is important, especially if there are sores in the mouth or throat.

Prompt identification and prompt discontinuation of the offending agent is essential to improve outcomes in patients with TEN.

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